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Sixteen cases of hepatoma presenting as craniospinal metastasis without obvioushepatic involvement were reviewed.Metastatic spread of hepatoma to the cerebrum was found in one case,to the cranium in six cases,and to the vertebrae in nine cases.All of these cases had mildly abnormal liver function when first evaluated.Of those patients with hepatoma,56%had evidence of hepatomegaly.Alpha fetoprotein was present,at levels greater than320 ng/ml,in 69%.Ninety four per cent died of the primary liver disease within one year.For any patient who develops cranial metastasis of unknown origin in a geographical area where hepatoma is a common disease, hepatoma should be considered in the differential diagnosis. |
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carcinoma of liver
hepatoma
hepatomegaly
life expectancy
low back pain
neoplasm,metastatic to base of skull
neoplasm,metastatic to CNS
neoplasm,metastatic to Dura
pain,abdominal
pain,back
pain,buttock
paraparesis
prognosis
radicular pain
skull,metastatic carcinoma to
spinal cord,compression of
spine,metastasis to
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